Ras model
0.1
  • Overview
  • The RAS Executable Model
    • EGFR
    • Ras
    • Raf
    • MAPK
  • Model scenarios
  • Model analysis
  • References
Ras model
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  • The RAS Executable Model (REM)
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The RAS Executable Model (REM)ΒΆ

  • EGFR
    • EGFR (minimal)
      • INDRA-assembled model components
  • Ras
    • Ras proteins are GTPases
      • Anatomy of Ras
      • Ras binds GTP and GDP
      • Ras converts GTP to GDP
      • Oncogenic Ras mutants have reduced GTP binding and GTPase activity
      • Post-translational modifications of the C-terminus
    • Ras regulation by GEFs
      • Identities of Ras-specific GEFs
      • Mechanism of GEFs
      • Rates of GEF activation
      • Specificity of RASGRF1 for Ras isoforms
    • Ras regulation by RasGAPs
      • RasGAPs for the Ras subfamily
      • Mechanism of accelerating hydrolysis
    • Ras (minimal)
      • INDRA-assembled model components
  • Raf
    • Raf activation by Ras
    • Vemurafenib inhibits RAF
      • References
    • RAF (minimal)
      • INDRA-assembled model components
  • MAPK
    • MAPK (minimal)
      • INDRA-assembled model components
    • MAPK module with MEK inhibition
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