SetupΒΆ

First we initialize the model:

from pysb import Model

Model()

Then we pull in the components for Ras:

from rasmodel.components import ras

ras.ras_monomers()
ras.rasgef_monomers()
ras.rasgap_monomers()
ras.nucleotide_monomers()

We include binding and hydrolysis for HRAS, NRAS, and KRAS:

ras.hras_binds_nucleotides(model)
ras.hras_hydrolyzes_gtp(model)
ras.kras_binds_nucleotides(model)
ras.kras_hydrolyzes_gtp(model)
ras.nras_binds_nucleotides(model)
ras.nras_hydrolyzes_gtp(model)

Because some in vitro experiments also contain RasGAPs (e.g., to measure hydrolysis rates), we include these as well:

ras.kras_rasgaps(model)