Ras model
0.1
  • Overview
  • The RAS Executable Model
    • EGFR
    • Ras
      • Ras proteins are GTPases
      • Ras regulation by GEFs
      • Ras regulation by RasGAPs
      • Ras (minimal)
    • Raf
    • MAPK
  • Model scenarios
  • Model analysis
  • References
Ras model
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RasΒΆ

Note

This section defines the component rasmodel.components.ras.

  • Ras proteins are GTPases
    • Anatomy of Ras
    • Ras binds GTP and GDP
    • Ras converts GTP to GDP
    • Oncogenic Ras mutants have reduced GTP binding and GTPase activity
    • Post-translational modifications of the C-terminus
  • Ras regulation by GEFs
    • Identities of Ras-specific GEFs
    • Mechanism of GEFs
    • Rates of GEF activation
    • Specificity of RASGRF1 for Ras isoforms
  • Ras regulation by RasGAPs
    • RasGAPs for the Ras subfamily
    • Mechanism of accelerating hydrolysis
  • Ras (minimal)
    • INDRA-assembled model components
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