Ras model
0.1
Overview
The RAS Executable Model
EGFR
Ras
Ras proteins are GTPases
Ras regulation by GEFs
Ras regulation by RasGAPs
Ras (minimal)
Raf
MAPK
Model scenarios
Model analysis
References
Ras model
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The RAS Executable Model (REM)
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Ras
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Ras
ΒΆ
Note
This section defines the component
rasmodel.components.ras
.
Ras proteins are GTPases
Anatomy of Ras
Ras binds GTP and GDP
Ras converts GTP to GDP
Oncogenic Ras mutants have reduced GTP binding and GTPase activity
Post-translational modifications of the C-terminus
Ras regulation by GEFs
Identities of Ras-specific GEFs
Mechanism of GEFs
Rates of GEF activation
Specificity of RASGRF1 for Ras isoforms
Ras regulation by RasGAPs
RasGAPs for the Ras subfamily
Mechanism of accelerating hydrolysis
Ras (minimal)
INDRA-assembled model components